India doctors Sasrutha: Describes the sweetness of urine in diabetic patients

Greece Thucydides: plague patients had recovered can prevent re-infection

Islamic physician Rhazes: Tian Hua infection recovery for life

Chinese doctors: by nasal inhalation of smallpox pustules dry swarf, the immune

Edwar Jenner：The first boy against smallpox using cowpox vaccination

Friedrich Wonler：The first biological substances such as urea

Justus Liebig：Development of quantitative chemical analysis technology

Jons Benzelius："Protein" terms proposed

Palu Ehrlich：Identification of mast cells, basic principles of immunity, side-chain antibody formation theory of antibody specificity

Ilya Mechnikov：Theory of phagocytosis, cell-mediated immunity theory

Louis Pasteur：First rabies vaccine, pathogen infection theory, theory of fermentation

Emilvon Behring：Use immune serum against diphtheria

Robert Koch：Tuberculin reaction of delayed allergic reaction

Jules Border：The lysozyme activity of antibody and complement

Rudolf Kraus：Toxin and antitoxin response, cloud and precipitation formation and precipitation of grain

Karl Landsteiner：Find a, b and O blood group system, the concept of Antigen and antibody and cell-mediated immune

Svante Arrhenius："Immunochemical" terms proposed

Lloyd Felton & GH Bailey：Antibody protein chemical properties and separation

Michael Heidelberger & Forrest Kendall：Describes the immunoprecipitation reaction

Astrid Fagraeus：Confirmed plasma b cell antibody production

Alert Coons & NH Kaplan：The development of immuno-fluorescence technology

Richard Gershon & Francis Crick：Found that the suppressor t cell

Bruce Glick：Lymphocytes are cells and humoral immune effector cells

Morton Simonsen & W Dempster：Dog kidney rejection (Graft-versus-host reaction)

James Waston和Francs Crick：Described the double helix structure of DNA

A Isaaca & J Lindemann：Found virus-infected cell produces interferon

Jean Dausset：Discovered the human leukocyte antigen

Rosalyn Yalow：The development of RIA technology

Renato Dulbecco：Development of modern tissue culture technology

Rodney Porter & Gerald Edelman：IgG description of the structure of antibodies

Noel Warnel et al：The immune response of t and b cells in synergy

Juliana Mancini，Angelo Carbonara和Josef Heremans：Using radial Immunodiffusion method quantitative immunochemistry of antigens

Kimishige & Teruko Ishizaka：Confirm that IgE is a reactive antibody

Eva Engvall & P Perlman：ELISA development

Cesar Milstein & Georges Kohler: preparation of monoclonal antibodies by hybridoma technology development

Frederich Sanger & Walter Gilbert: nucleic acid sequencing

WHO report: the worldwide eradication of smallpox

Of the immunosuppressant Cyclosporine found in 1983 and approved a revolutionary immunosuppressant drugs, which allows organ transplants from the routine operation of ancient fairy tales become reality.Organ transplant patients, particularly kidney and other organ transplantation escape Allo exclusion threshold of life and death, saved the lives of millions of patients.

Susumu Tonegawa，Hood et al：Find the genetics of antibody diversity, confirmed the immunoglobulin genes

Kary Mullis: the use of PCR technology to amplify DNA

United States national institutes of health and the Department of energy: launched the human genome project

Human genome project: the human genome sequence published

Molecular revolution: PCR and gene cloning of monoclonal antibody technology combined, genetically modified and applied to diseases;Genetic engineering to produce monoclonal antibodies for immunotherapy;Recombinant DNA vaccines, gene therapy