INTAVIS MultiPep CF

Solutions：Proteomics,Immunology,Pharmaceutical ,Life Science

Origin：Germany

The MultiPep CF is a fully automated peptide synthesizer with a unique column module that allows the synthesis of long and difficult sequences. Optional UV monitoring in real-time enables the optimization of reaction parameters like deprotection and coupling times during the synthesis. The continuous monitoring can be used to automatically adapt the number of washing steps as well. This leads to a significant reduction of solvent consumption. The MultiPep CF is the only peptide synthesizer with a real-time continuous UV monitoring with a long life LED light source.

The MultiPep CF can be upgraded with a 72 column module for the parallel synthesis of peptides at 10-500µmol scales. The instrument is based on a pipetting robot with a single needle. A multi-channel manifold is used for rapid solvent delivery and washing via a robust pump connected to a ceramic 6-port valve.

The column module allows the parallel synthesis in 72, 36 or 18 disposable filter columns at 10-100, 50-300 or 100-500µmol scales respectively. Vortexing and heating options ensure reliable agitation of reagents and resin by optimizing reaction conditions at larger scales.

The instrument covers the requirements of core facilities, research laboratories and custom synthesis houses. Up to 13 solvent and reagent bottles offer the flexibility to run complex chemistry protocols.

Available modules:

→ 1-Column Module: single column, 0.05-2mmol scales; optional real-time UV monitoring

MultiPep CF Continuous flow synthesis with real-time UV monitoring option.

The MultiPep CF is a fully automated peptide synthesizer with a unique column module that allows the synthesis of long and difficult sequences. Optional UV monitoring in real-time enables the optimization of reaction parameters like deprotection and coupling times during the synthesis. The continuous monitoring can be used to automatically adapt the number of washing steps as well. This leads to a significant reduction of solvent consumption. The MultiPep CF is the only peptide synthesizer with a real-time continuous UV monitoring with a long life LED light source.

·Mixing by vortexing and continuous flow

·Real-time UV monitoring option

·Inert gas option

·Large scale synthesis (0.05 - 2mmol)

·Disposable columns (12, 25 and 40ml)

→ Column Module: multiple synthesis upgrade, up to 72 peptides; 10-500µmol scales

MultiPep CF Column Upgrade

The upgrade kit allows peptide synthesis on resin in up to 72 columns at synthesis scales ranging from 10-500µmol using Fmoc chemistry. The columns can be handled individually during work-up which simplifies cleavage and filtration from the resin. For the column module an orbital shaker and a heating unit are available as additional options. Peptides with difficult sequences can be synthesized with higher purities by elevated reaction temperatures. The column module is delivered complete with a basic set of consumables and protocols. The exchange for one of the other modules can be accomplished in a couple of minutes.

·72x 2 or 5 ml columns for 10-100 µmol scales

·36x 10 ml columns for 50-300 µmol scales

·18x 25 ml columns for 100-500 µmol scales

·Software controlled vortexing speeds

·72 positions thermo-block for 2 and 5 ml column